Research on the Active ingredients used in the KALME range.
KALME uses a patented plant extract from freshly picked Caper Buds called Derma Sensitive.
An earlier study ¹ showed that the caper buds offer significant anti-inflammatory activity and are almost as effective as a pharmacologically recognised anti-inflammatory oxyphenbutazone. Capers induced a 50% reduction in inflammation, as opposed to 66% for the pharmaceutical reference.
The most active components of capers were then isolated ² and fortified by using a specialised extraction technique.
This fortified caper extract was then tested on In Vivo on a panel of 20 people with sensitive, reactive skin, prone to discomfort and redness. The product was applied to one side of the face, twice a day for 28 days. A cream containing a reference calming active, Bisabolol at 0.5%, was applied using the same protocol to the other side of the face.
After 4 weeks dermatologists found that Derma Sensitive treated skin had seen a significant improvement, of between 10 and 70%.
In particular, the researchers found redness had greatly reduced by 70% after the treatment.
The conclusion is that the KALME Range significantly reduces redness, decreases skin reactivity and improves skin comfort.
¹ Ageel A.M. et al. Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents and Actions. 17(3-4), 1985: 383-384.
² Al-Said M.S. et al. Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Pharmazie. 43(9), 1988: 640-641.
KALME incorporates an ingredient called INDINYL® which is an extract of Cassia Angustifolia, an exotic Indian plant, to provide 24 hour moisturisation.
Acne is a common symptom of rosacea. Unlike normal acne which is often connected to greasy skin rosacea is a dry skin condition and effective moisturisation is vital for Rosacea sufferers.
INDINYL is a natural vegetable based version of hyluronic acid which is one of the main building blocks of the skin and is vital for healthy skin function.
In trials French researchers from Laloratoires Sérobiologiques who developed INDINYL found that it had an immediate and prolonged moisturizing effect over 24 hours on superficial epidermal layers. The extract improved the long-term moisturisation of the skin by improving the capacity of the stratum corneum to retain onto water.